1. Lymphocyte Depleted Hodgkin Lymphoma (LDHL)
The Lymphocyte depletion subtype is a very rare form of Hodgkin Lymphoma that makes up only about 1% of those affected by the disease. It affects older people and is often diagnosed in an advanced stage when the lymphoma has affected different organs of the body. It is also more common in those who are HIV affected.
2. Lymphocyte-rich Classic Hodgkin Lymphoma (LRCHL)
This is another uncommon subtype that makes up about 5-6% of Hodgkin patients. It is more common in males and affects people most commonly in their thirties or forties. Most individuals are diagnosed in early stages and response to treatment is excellent.
3. Mixed Cellularity Hodgkin Lymphoma (MCHL)
This is another common type of Hodgkin Lymphoma. 15-30% of those affected have mixed cellularity disease. This type is more common in developing countries. People of any age may be affected. Males and females are equally affected. This type of disease is more likely to involve the abdomen than the more common nodular sclerosing variety, and less likely to involve nodes within the chest.
4. Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL)
Now considered to be a special type of Hodgkin disease that is different from the other types mentioned above, this variant accounts for 4-5% of all cases of Hodgkin disease. According to pathologists this type has many similarities with Non-Hodgkin Lymphoma (NHL). In all clinical aspects, however, the features are similar to the lymphocyte-rich type of Hodgkin lymphoma. Most individuals are diagnosed early and do very well after treatment.
5. Nodular Sclerosing Hodgkin Lymphoma (NSHL)
This is the most common type of Hodgkin Lymphoma. In the developed countries 60-80% of the people affected by Hodgkin disease have the Nodular Sclerosing subtype. It is commoner in females and mostly affects younger people – adolescents and young adults. The disease mainly affects nodes in the neck or armpits, or within the chest.