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A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.

Stage I Prostate Cancer

Treatment of stage I prostate cancer may include the following:

1. A clinical trial of high-intensity focused ultrasound.
2. A clinical trial testing new types of treatment.
3. External-beam radiation therapy.
4. Implant radiation therapy.
5. Watchful waiting or active surveillance.
6. Radical prostatectomy, usually with pelvic lymphadenectomy, with or without radiation therapy after surgery. It may be possible to remove the prostate without damaging nerves that are necessary for an erection.

Stage II Prostate Cancer

Treatment of stage II prostate cancer may include the following:

1. A clinical trial of radiation therapy with or without hormone therapy.
2. A clinical trial of ultrasound -guided cryosurgery.
3. A clinical trial of high-intensity focused ultrasound.
4. A clinical trial of proton beam radiation therapy.
5. External-beam radiation therapy with or without hormone therapy.
6. Implant radiation therapy.
7. Watchful waiting or active surveillance.
8. Clinical trials testing new types of treatment, such as hormone therapy followed by radical prostatectomy.
9. Radical prostatectomy, with or without pelvic lymphadenectomy. Radiation therapy may be given after surgery. It may be possible to remove the prostate without damaging nerves that are necessary for an erection.

Stage III Prostate Cancer

Treatment of stage III prostate cancer may include the following:
  1. A clinical trial of radiation therapy.
  2. A clinical trial of ultrasound -guided cryosurgery.
  3. A clinical trial testing new types of treatment.
  4. External-beam radiation therapy with or without hormone therapy.
  5. Hormone therapy.
  6. Watchful waiting or active surveillance.
  7. Radical prostatectomy, with or without pelvic lymphadenectomy. Radiation therapy may be given after surgery.
  8. Radiation therapy, hormone therapy, or transurethral resection of the prostate as palliative therapy to relieve symptoms caused by the cancer.


Stage IV Prostate Cancer

Treatment of stage IV prostate cancer may include the following:

1. A clinical trial of radical prostatectomy with orchiectomy.
2. External-beam radiation therapy with or without hormone therapy.
3. Hormone therapy.
4. Watchful waiting or active surveillance.
5. Radiation therapy or transurethral resection of the prostate as palliative therapy to relieve symptoms caused by the cancer.
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